Casma’s first-in-class TRPML1 agonist represents a new therapeutic approach for targeting lysosomal dysfunction in genetically driven neurodegenerative diseases CAMBRIDGE, Mass., June 5, 2025 — Casma Therapeutics, Inc., a biotechnology company engaging the autophagy and lysosomal systems to develop innovative new medicines, today announced the nomination of its first development candidate, CSM-101, a first-in-class TRPML1 agonist. […]
“Vipergen is a leader in DNA-encoded library technologies, and we are delighted to be working with them to develop novel chemistry for our programs.” said Jeff Saunders, PhD, SVP of Drug Discovery at Casma. “We look forward to drawing on Vipergen’s expertise as we create breakthrough products for patients by harnessing the power of the autophagy pathway.”
“We are pleased to be selected by Casma, a leading company harnessing the natural cellular process of autophagy to design new medicines that arrest or reverse the progression of multiple disorders,” said Nils Hansen, PhD, Chief Executive Officer of Vipergen. “Our DNA-encoded library technology can introduce novel chemistry into Casma’s medicinal chemistry program that deliver high quality hits and leads for challenging protein targets that address important unmet medical needs. We look forward to working with Casma to create additional pathways for uncovering small-molecule product candidates.”
About Casma Therapeutics
Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development. Casma has developed a novel targeted degradation platform that utilizes the autophagosome to degrade disease causing aggregates, dysfunctional organelles and other large and complex difficult to drug targets. In addition, Casma uses several other approaches to intervene at strategic points in the autophagy-lysosome system to improve the cellular process of enhancing membrane repair. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of multiple disorders. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass. Additional investors include The Column Group, Eventide Asset Management and Schroder Adveq. For more information, please visit www.casmatx.com.
About Vipergen ApS
Vipergen is a world leading provider of small molecule drug discovery services based on DNA-encoded library (DEL) technologies. Vipergen is finding tractable hits/leads for your pharmaceutical relevant targets, using three proprietary 2nd and 3rd generation DEL technologies. Vipergen is the first and only company capable of screening DELs inside a living cell. Vipergen is offering different business models, including simple Fee-For-Service. In 2015-20 >40 deals signed, including with top-5 pharma in both USA, EU and Japan. For further details about Vipergen and the YoctoReactor®/ Binder Trap Enrichment®/ cellular Binder Trap Enrichment® drug discovery technology platforms please visit www.vipergen.com.
Contacts
Investor and Media Contact
Vipergen Contact:
Nils Hansen, PhD, Chief Executive Officer
Vipergen ApS
Email: nha@vipergen.com
Phone: +45 2523 6680
Casma Therapeutics Contact:
Courteney Backstrom
Casma Therapeutics, Inc.
Email: cbackstrom@casmatx.com
Phone: +1 857-777-4248
Keep reading:
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June 5, 2025Casma Therapeutics Nominates CSM-101 as a Development Candidate for the Treatment of Rare and Common Forms of Parkinson’s Disease
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April 17, 2024Casma Therapeutics to Participate at 23rd Annual Needham Virtual Healthcare Conference and at UBS Virtual Targeted Protein Degradation Day
CAMBRIDGE, Mass., April 17, 2024 – Casma Therapeutics, Inc., a biotechnology company engaging the autophagy/lysosomal system to provide innovative new medicines, today announced that Frank Gentile, PhD, Chief Executive Officer, presented and participated in one-on-one meetings at the 23rd Annual Needham Virtual Healthcare Conference on April 5, 2024. Frank Gentile, PhD, will also attend and participate in […]