Careers

Department: Drug Discovery                   

Reports to: Principal Scientist, Drug Discovery

Location: Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

We are seeking an exceptional biochemist to join our team. You will be an integral part of drug discovery programs that lead to the identification of novel therapeutic targets and drug candidates for clinical development. As a newly founded and fast-growing startup, you will have numerous growth opportunities and your voice will actively contribute to the company direction. We are looking for someone who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Responsibilities

• Contribute to our efforts in the conceptual design, development, and implementation of biochemical assays.
• Lead efforts to elucidate regulatory mechanisms of protein complex activation in the context of protein and small molecule interactions.
• Build positive relationships and work directly with our external partners – both academic and CROs – to execute Casma’s scientific goals.
• Provide enzymology expertise and interact closely with exploratory cell biologists and medicinal chemists as a member of drug discovery project teams.

Requirements + Qualifications

• BS, MS or PhD with 5+ years of drug discovery and 2-5 years of project management.
• Hit-to-lead characterization of small molecule candidates with multiple projects. Specific familiarity with the biophysical properties of large protein complexes is highly desirable.
• A strong background in biochemistry including in-depth understanding of enzyme kinetics, and mechanism-of-action studies. Familiarity with interpretation of protein structural models is a plus.
• Experience with and capability to work with outside vendors, including CROs.
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first mentality, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:                   Biology
Reports to:                       CSO
Location:                          Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

The Vice President (VP) of Biology will play a wide-ranging role in helping to develop a mature pipeline of drug candidates for Casma. The VP will contribute to all stages of small molecule drug discovery and early development including target ID and validation, hit discovery and lead optimization through to IND. This will require that the candidate has 15+ years of experience progressing therapeutic programs into the clinic. An affinity for discovery biology and basic science is of critical importance. The VP will be adept at working in a non-hierarchical environment where teamwork and efficient decision making are of the essence. In addition to line management responsibilities, the VP will be expected to influence overall Company strategy and engage with key external partners. We are seeking a candidate who will share our excitement about the science, champion our culture, and honor our commitment to patients.

Responsibilities

• Using an approach grounded in objectivity and scientific rigor, oversee all internal and external biology activities focused on the discovery of novel targets and small molecule modulators of the autophagy pathway.
• Provide leadership, strategic oversight, resource management, and organizational framework to ensure timely decision making on projects.
• Identify, support, manage and develop talent among team; act as a resource and mentor to team members by providing guidance, instruction, feedback and ongoing coaching; encourage visionary thinking. Value the advancement of our programs and our people.
• Preserve and promote current model of participative decision making in an organization where siloes are nonexistent and discouraged.
• Professionally represent the organization externally in collaborations and conferences, board of directors and scientific advisory board meetings.

Requirements + Qualifications

• PhD in Biological Sciences, MD, or MD/PhD with 15+ years of industry experience working in the pharmaceutical and/or biotechnology field as a biologist
• Extensive track-record of leading drug discovery programs through to IND and adopting highly innovative approaches to answering complex biological questions
• History of publications and conference presentations
• Proven ability to work within a matrix management structure to influence programs
• Demonstrated ability to lead through others and develop emerging leaders within organization
• Outstanding interpersonal and collaboration skills
• Ability to work productively and collaboratively with potential corporate partners/external collaborators
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment with people who are motivated to succeed together as a team
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:     Business Development
Reports to:        COO/Head of Business Development
Location:            Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

The Director of Business Development & Corporate Strategy will develop and execute on key strategies and lead the design and implementation of new initiatives and operational projects. This will be a high-profile role where the candidate will gain firsthand strategic and operating experience while helping to build a premier biotechnology company. While this high energy individual will wear many hats and have the capacity to drive numerous complex projects forward simultaneously, the focus is on driving multiple transactions for key corporate partnerships. This position will provide both strategic and operational excellence working closely with senior management and business partners. This person will play an instrumental role in critical outreach to potential partners and eventually transactions We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Responsibilities

• Contribute to the refinement, articulation, and execution of Casma’s business and science strategy.
• Participate in corporate partnering efforts including negotiations, due diligence, term sheet construction and final agreements.
• In conjunction with company leadership and R&D team, craft external partnering and investor presentations.
• Provide analytic support by building and updating business/product models, conducting market analysis, and performing competitive intelligence.
• Ensure coordination of activities and deliverables across all functions.
• Collaborate cross-functionally to develop and manage the R&D budget, including resource tracking and scenario planning.
• Other duties, as assigned.

Requirements + Qualifications

• MS/MBA, MD or PhD preferred
• 8-10 years of relevant biotech or pharmaceutical industry experience
• At least 4-6 years in business development or corporate strategy function
• Relevant transactional experience (in-licensing, M&A, R&D partnership)
• Operational experience and familiarity with the drug development process
• Experience setting and maintaining budgets
• Ability to influence across multiple functions, effectively work with different personalities and styles, and efficiently prioritize activities
• Comfortable navigating complexity and ambiguity in a fast-paced environment
• Knowledge of project management and presentation tools (Microsoft Project, Excel, PowerPoint)
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:     Business Development
Reports to:        COO/Head of Business Development
Location:            Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

The Associate Director of Business Development & Corporate Strategy will develop and execute on key strategies and lead the design and implementation of new initiatives and operational projects. This will be a high-profile role where the candidate will gain firsthand strategic and operating experience while helping to build a premier biotechnology company. This high energy individual will wear many hats and have the capacity to drive numerous complex projects forward simultaneously. This position will provide both strategic and operational excellence working closely with senior management and business partners. This person will play an instrumental role in organizing and advancing critical R&D programs, facilitating timely and impactful decisions, and establishing and leading the development of overall portfolio/BD strategy at Casma. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Responsibilities

• Contribute to the refinement, articulation, and execution of Casma’s business and science strategy.
• Drive corporate partnering efforts (e.g., negotiation, coordination of due diligence activities, drafting research plans, financial analysis, term sheet drafting, etc.).
• In conjunction with company leadership and R&D team, craft external partnering presentations.
• Provide analytic support by building and updating business/product models, conducting market analysis, and performing competitive intelligence.
• In partnership with the project leaders, guide program strategy, set program goals and lead team decision-making for Casma’s discovery and early development programs.
• Act as Alliance Manager with pharmaceutical companiess, key research collaborators, suppliers and licensors.
• Ensure coordination of activities and deliverables across all functions.
• Collaborate cross-functionally to develop and manage the R&D budget, including resource tracking and scenario planning.
• Other duties, as assigned.

Requirements + Qualifications

• MS/MBA, MD or PhD preferred
• 5-8 years of relevant biotech or pharmaceutical industry experience
• At least 2-3 years in business development or corporate strategy function
• Operational experience and familiarity with the drug development process
• Experience setting and maintaining budgets
• Ability to influence across multiple functions, effectively work with different personalities and styles, and efficiently prioritize activities
• Comfortable navigating complexity and ambiguity in a fast-paced environment
• Knowledge of project management and presentation tools (Microsoft Project, Excel, PowerPoint)
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:                   Biology

Reports to:                       Scientist, Biology

Location:                          Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

We are seeking a highly motivated, Research Associate to participate in drug discovery programs that lead to the identification of new targets and drug candidates for clinical development. The individual should possess strong core competencies in cell biology, molecular biology, assay development. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Responsibilities

• Cell culture and cell line development using retro- and lenti-virus, CRISPR and downstream analysis of autophagy and signaling.
• Perform western blotting, FACS and imaging analysis to analyze autophagy and specific target activity in primary cells and cell lines.
• Aid in conducting genome-wide CRISPR screens for novel target ID.
• Validate hits from CRIPSR screens for autophagy regulators to aid target ID efforts.
• Use mouse tissue to both aid in the development of novel biomarkers and analyze key targets by protein and gene expression.
• Work to validate hits from high throughput screen using medium-throughput biochemical and high content cellular imaging assays.
• Develop tools to identify compound MOA.
• Work with primary neurons and patient derived cells to assess target engagement and disease efficacy.
• Other duties, as assigned.

Requirements + Qualifications

• Bachelor’s degree in biology or related discipline plus 3-5 years or Master’s degree plus 1-3 years of experience conducting high quality science in an industry setting
• Proficient in mammalian cell culture and cell line generation
• Experience with western blotting, immunoprecipitation, and plasmid preparation
• Expertise in genetic manipulation using CRISPR, shRNA, lentiviral/retroviral transduction or RNAi
• Hands-on knowledge of flow cytometry and FACS analysis techniques preferred
• Excellent organizational skills and attention to detail
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:                   Biology

Reports to:                       Scientist, Biology

Location:                          Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

We are seeking a highly motivated, Research Associate to participate in drug discovery programs that lead to the identification of new targets and drug candidates for clinical development. The individual should possess strong core competencies in cell biology, molecular biology, assay development. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Responsibilities

• Responsible for maintaining, transfecting, and transducing mammalian cell lines and primary neurons.
• Make solutions, buffers, and compound dilutions to support electrophysiology assays.
• Work under the guidance of a scientist to support characterization of ion channels using electrophysiology (manual and high content) assays in the lab.
• Hit validation by high content imaging assays.
• Other duties, as assigned.

Requirements + Qualifications

• Bachelor’s degree in biology or related discipline plus 3-5 years or Master’s degree plus 1-3 years of experience conducting high quality science in an industry setting
• Proficient in mammalian cell culture and cell line generation
• Experience with western blotting, immunoprecipitation, and plasmid preparation
• Expertise in genetic manipulation using CRISPR, shRNA, lentiviral/retroviral transduction or RNAi
• Hands-on knowledge of flow cytometry and FACS analysis techniques preferred
• Excellent organizational skills and attention to detail
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department: R&D
Reports To: CSO
Location: Cambridge, MA

Casma Overview
Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role
Casma Therapeutics is seeking an experienced drug discovery scientist with deep knowledge evaluating therapeutic efficacy in rodent models for rare genetic diseases, lysosomal storage diseases and metabolic disorders. The candidate will also be responsible for defining and executing an autophagy biomarker discovery strategy and should adopt a highly collaborative approach to establish strong relationships with external partners and the internal drug discovery team.  This is a unique opportunity to join an innovative start up biotech from inception to develop novel therapeutics to meet currently unmet medical needs.

Responsibilities

• Collaborate with the Casma team to define and execute a strategy to evaluate efficacy in relevant rodent models.
• Design and supervise the execution of studies and fully collaborate with drug discovery team to reach critical decision points leading to nomination of development candidates.
• Develop a strategy to discover and validate autophagy biomarkers suitable for clinical development.

 Requirements + Qualifications

• 7-10 years of relevant work experience in biotech/ pharma
• Experience employing molecular profiling approaches to develop pathway-dependent biomarkers suitable for use in clinical development
• Experience collaborating with biologists and chemists to generate in vivo target validation data using genetic and pharmacological methods.
• Multiple examples of supporting medicinal chemistry efforts to identify develop candidates
• Prior experience and record of accomplishment functioning in cross functional teams and willingness to adopt a hands-on approach to deliver in a start-up biotech environment
• Prior experience in successfully implementing, utilizing and leveraging outsourcing strategies
• Significant expertise working across disease indications with specific focus on RGD, lysosomal storage disease and metabolic diseases
• Extensive know-how using biochemical, molecular and behavioral endpoints is essential
• Solid understanding of drug metabolism, PD biomarkers and endpoint correlations required
• Strong written, oral and public speaking communication skills
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first mentality, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity
Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!
If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:     Biology
Reports to:        Head of Biology
Location:           Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

The Scientist I, Biology will be an integral part of drug discovery programs that lead to the identification of novel therapeutic targets and drug candidates for clinical development. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Requirements + Qualifications

• PhD in cell biology, biochemistry, or cancer biology with 0-2 years of experience conducting high quality science in an industry setting
• Strong core competencies in molecular biology, cell biology, assay development, and medium throughput compound screening
• Proficient in mammalian cell culture, primary cells, cell line development, and generation of disease models
• Strong expertise in genetic manipulation using technologies such as CRISPR, shRNA, lentiviral/retroviral transduction, RNAi
• Hands-on knowledge of flow cytometry and FACS analysis techniques
• Experience in western blotting and immunoprecipitation
• Previous experience with live cell imaging, high content imaging, and FRET assays favorably considered
• Previous experience working with mouse models, compound dosing, tissue processing, and immunohistochemistry a plus
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:    Drug Discovery
Reports to:        SVP of Drug Discovery
Location:           Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

The Senior Scientist, Medicinal Chemistry is responsible for the design and synthesis of compounds that lead to the identification of drug candidates for clinical development. The person in this role will be an integral part of drug discovery programs that lead to the identification of novel therapeutic targets and drug candidates for clinical development. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Responsibilities

• Execute on medicinal chemistry ideas to identify drug candidates for clinical development.
• Mentor and supervise associate scientists and serve as a source of synthetic chemistry expertise.
• Manage external chemists and collaborations resulting in the delivery of drug candidates on aggressive time lines.
• Actively follow scientific advancements and literature within the area of research interest.
• Other duties, as assigned.

Requirements + Qualifications

• PhD in Organic Chemistry and 7-10 years of relevant pharmaceutical industry experience
• Demonstrated exemplary skills in all aspects of organic and medicinal chemistry techniques including parallel library design and synthesis, structure-based design, analytical methods and purification methods
• Experience functioning within a strong multi-disciplinary team and utilizing cross-functional information, such as cellular data and ADME/DMPK, to drive medicinal chemistry strategies
• Experience in functioning within a matrix driven organization required
• Demonstrated strong leadership skills and a track record of success in all aspect of medicinal chemistry and drug discovery from hit identification, hit to leads and especially in lead optimization
• Demonstrated record of success toward clinical candidates
• Experience in managing external FTE resources in chemistry is a plus
• Strong interpersonal, organizational and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:    Drug Discovery
Reports to:        SVP of Drug Discovery
Location:           Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

We are currently seeking a highly motivated, creative, and experienced Senior Scientist, Computational Chemist to build a cutting-edge modeling and computational chemistry effort to drive the drug discovery efforts for multiple programs. In addition to significant experience in compound design toward successful discovery programs and expertise in modeling and computational technologies, the position will require the candidate to have the capacity to work independently within a collaborative environment and demonstrate leadership, creativity and adaptability in her/his scientific work. In this role, the successful candidate will provide scientific leadership on a day-to-day basis within a multi-disciplinary drug design team guiding an international, virtual synthetic chemistry team.

Responsibilities

• Define and acquire appropriate modeling software to support medicinal chemistry.
• Execute structure-based drug design using co-crystal structures.
• Create pharmacophore, homology, QSAR and other empirical models.
• Interact with experienced drug design team to generate structural hypotheses.
• Access and manipulate crystallographic data, ligand docking to active sites and homology modeling.
• Other duties, as assigned.

Requirements + Qualifications

• D in computational chemistry, computational biology or a related field, with 8+ years of related work experience within a pharmaceutical or biotech environment
• Proven leadership experience managing projects and people; must be capable of building computational chemistry as a function within the organization
• Expertise in applying in silico techniques for the process of hit identification through advanced lead optimization
• A solid understanding of chemometrics, which includes QSAR methodologies, data mining and visualization, protein modeling, molecular docking, library design, conformational analysis, pharmacophore development, and 2D and 3D similarity
• A sound understanding of bioinformatics and computational biology including gene expression data analysis and mining biological pathways to enhance target knowledge (GeneGO, Ingenuity)
• Background in medicinal chemistry and basic knowledge of synthetic organic chemistry
• The ability to work independently as effectively as being able to collaborate in multidisciplinary teams
• Strong analytical and problem-solving skills and scientific creativity
• Programming skills in C/C++/C#, Java and scripting in Perl/Python and Pipeline Pilot
• Strong interpersonal, collaboration, and organizational skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:     Drug Discovery
Reports to:        Principal Scientist, Drug Discovery
Location:           Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

The Senior Associate Scientist/Scientist will be an integral part of drug discovery programs that lead to the identification of novel therapeutic targets and drug candidates for clinical development. The person in this position will contribute to our efforts in the conceptual design, development, and implementation of biochemical assays, small to medium scale screening of compounds, and investigation of enzymatic mechanisms of action. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Responsibilities

• Play a leading role to ensure biochemical/biophysical characterization of enzymes in the context of protein and small molecule interactions.
• Build positive relationships and work directly with our external partners – both academic and CROs – to execute Casma’s scientific goals.
• Interact closely with exploratory cell biologists and medicinal chemists to elucidate relevant intracellular biochemistry and provide expertise as a member of drug discovery project teams
• Other duties, as assigned.

Requirements + Qualifications

• Master’s degree plus 5-7 years’ experience conducting high quality science in an industry setting or Ph.D. with 2-3 years in an industry setting
• Strong core competencies in biochemical or biophysical assay development and medium throughput compound screening
• Comfort and familiarity with laboratory automation and data handling
• Experience in drug discovery with hit-to-lead characterization of small molecule candidates
• Specific familiarity with the properties of protein complexes is highly desirable
• A strong background in biochemistry and biophysical chemistry, including in-depth understanding of enzyme kinetics, and mechanism-of-action studies; familiarity with interpretation of protein structural models is a plus
• Integrity, transparency, curiosity and focus
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly-creative and enthusiastic start-up environment
• Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.

Department:     Biology
Reports To:        Scientist/Scientist II, Biology
Location:            Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

Your Role

We are seeking a highly motivated Research Associate/Senior Research Associate to be an integral part of drug discovery programs that lead to the identification of novel therapeutic targets and drug candidates for clinical development. As a newly founded and fast-growing startup, you will have numerous growth opportunities and your voice will actively contribute to the company direction. We are looking for someone who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.

Requirements + Qualifications

• Bachelor’s degree plus 4-6 years of experience or Master’s degree plus 2-5 years of experience conducting high quality science in an industry setting
• Strong core competencies in molecular biology, cell biology, assay development, and medium throughput compound screening
• Proficient in mammalian cell culture, primary cells, cell line development, and generation of disease models
• Strong expertise in genetic manipulation using technologies such as CRISPR, shRNA, lentiviral/retroviral transduction, RNAi
• Hands-on knowledge of flow cytometry and FACS analysis techniques
• Experience in western blotting and immunoprecipitation
• Previous experience with live cell imaging, high content imaging, and FRET assays favorably considered
• Previous experience working with mouse models, compound dosing, tissue processing, and immunohistochemistry a plus
• Strong interpersonal and communication skills
• Excellent organizational skills and attention to detail
• Strong interpersonal and collaboration skills
• Clear and effective verbal and written communication skills
• A demonstrated ability to think logically and critically
• Ability to successfully participate in a highly creative and enthusiastic start-up environment
• Exemplify a patient first mentality, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to careers@casmatx.com.