Research Associate, Electrophysiology

Department:                   Biology

Reports to:                       Scientist, Biology

Location:                          Cambridge, MA

Casma Overview

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development that will profoundly impact the lives of patients. Autophagy is a conserved cellular process that contributes to overall organismal health. Inefficient autophagy flux or defects in lysosomal homeostasis are observed in numerous pathologies, e.g., neurodegeneration, metabolic disorders, inflammation, and muscle degeneration. Casma uses several approaches to intervene at strategic points throughout the autophagy-lysosome system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications. Casma was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

The Role

We are seeking a highly motivated, Research Associate to participate in drug discovery programs that lead to the identification of new targets and drug candidates for clinical development. The individual should possess strong core competencies in cell biology, molecular biology, assay development. We are seeking a qualified candidate who will share our excitement about the science, contribute to our culture, and honor our commitment to patients.


  • Responsible for maintaining, transfecting, and transducing mammalian cell lines and primary neurons.
  • Make solutions, buffers, and compound dilutions to support electrophysiology assays.
  • Work under the guidance of a scientist to support characterization of ion channels using electrophysiology (manual and high content) assays in the lab.
  • Hit validation by high content imaging assays.
  • Other duties, as assigned.

Requirements + Qualifications

  • Bachelor’s degree in biology or related discipline plus 3-5 years or Master’s degree plus 1-3 years of experience conducting high quality science in an industry setting
  • Proficient in mammalian cell culture and cell line generation
  • Experience with western blotting, immunoprecipitation, and plasmid preparation
  • Expertise in genetic manipulation using CRISPR, shRNA, lentiviral/retroviral transduction or RNAi
  • Hands-on knowledge of flow cytometry and FACS analysis techniques preferred
  • Excellent organizational skills and attention to detail
  • Strong interpersonal and collaboration skills
  • Clear and effective verbal and written communication skills
  • A demonstrated ability to think logically and critically
  • Ability to successfully participate in a highly-creative and enthusiastic start-up environment
  • Exemplify a patient-first focus, courage, integrity, drive, and respect for all team members

Company Values + Culture

Courage to listen, learn, lead, Awesome science, Strength through collaboration,

Medical breakthroughs for patients, Always do the right thing

We have created and are sustaining a creative scientific culture where we recognize and reward our “Casmaniacs” for exemplifying our Core Values, and we accelerate our professional growth through coaching, development, and frequent feedback. Our plan of nurturing the fiercest, most talented and diverse Casmaniacs is coming to fruition before our very eyes.

Casmaniacs are provided competitive salaries, stock options, bonus eligibility, and excellent benefits including health, dental and vision insurance, life insurance, long-term disability, 401(k), unlimited vacation, generous parental leave, commuter reimbursement, professional development, philanthropic opportunities, and most importantly a sense of community.

Equal Employment Opportunity

Casma provides equal employment opportunities to all employees and applicants for employment without regard to race, color, national origin, religion, sexual orientation, gender, gender identity or expression, age, veteran status, disability, pregnancy or conditions related to pregnancy, or genetics.

Apply Today!

If you would like to learn more, please send us your resume and anything else you would like to share to